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Therapeutic Area

Rheumatoid arthritis

Eligibility Criteria

  • Male or females 18+ years old
  • Diagnosis of Rheumatoid Arthritis
  • Received <3 doses of Methotrexate
  • On stable doses of non-steroidal anti-inflammatory medications, paracetamol, oral corticosteroids (equivalent of prednisolone ≤10mg per day) or inhaled corticosteroids
  • No prior treatment with tofacitinib, baricitinib, filgotinib or any biologic medications
  • No prior history of Hepatitis B or C, HIV, TB or recurrent shingles
  • No history of malignancy (non-malignant skin cancers are acceptable) or organ transplant

Trial Details

5 Years
Year 1: Monthly Visits
Year 2 to 5: Quarterly Visits

Status

Currently recruiting Register

Therapeutic Area

Sjögrens Syndrome

Eligibility Criteria

• Male or females 18+ years old
• Diagnosis of Sjögrens Syndrome
• No prior treatment with abatacept or anti-CD28 therapy
• No current diagnosis of Hepatitis B or C, HIV or TB
• No history • No history of recurrent shingles

Trial Details

1 Year
Monthly Visits

Status

Currently recruiting Register

Therapeutic Area

Giant Cell Arteritis (GCA)

Eligibility Criteria

  • Male or females 50+ years old
  • Diagnosis of Giant Cell Arthritis
  • Receiving or able to initiate prednisone treatment (minimum dose = 20mg/day)
  • No prior treatment with tocilizumab or other anti-IL-6 agents
  • No current diagnosis of Hepatitis B or C, HIV or TB
  • No history of known demyelinating diseases such as multiple sclerosis or optic neuritis
  • No history • No history of organ transplant

Trial Details

2 Years
Year 1: Monthly Visits
Year 2: Six-Monthly Visits

Status

Currently recruiting Register

Therapeutic Area

Non-radiographic axial Spondyloarthritis

Eligibility Criteria

• Male or females 18+ years old
• Inflammatory back pain for 6+ months
• Willingness to undergo an MRI
• Inadequate response or intolerance to >2 non-steroidal anti-inflammatory medications
• Patients taking Methotrexate (≤ 25 mg/week) or sulfasalazine (≤ 3 g/day) must have taken 3+ months and have been on a stable dose for at 4+ weeks
• Patients taking corticosteroids have to be on a stable dose of ≤10 mg/day prednisone (or equivalent) for 2+ weeks before randomization
• No current diagnosis of Hepatitis B or C, HIV or TB
No history < 5 years of malignancy (non-malignant skin cancers are acceptable)

Trial Details

2 Years
Year 1: Monthly Visits
Year 2: Quarterly Visits

Status

Currently recruiting Register